It is a special day for Luì – Luì is finally about to receive his diploma as a scientist, and as usual Sofì is by his side to cheer and encourage him. Of course, the event cannot be missed by Pongo either, their lifelong friend. Once again, however, Mr. S and the faithful Perfidia try to sabotage Me Against You but Sofì, with her fairy powers, and Luì, with the best technology worthy of a true scientist, will give their enemies a hard time. Something goes wrong, however, and magic catapults everyone to distant places and eras…lost in time! On this magical journey the Me Against You will discover they have new friends and meet a fierce new enemy. A fantastic and exciting movie adventure for Luì and Sofì, full of surprises and with lots of fun for their little fans and all families.